ICOS and cancer: The results indicated that immunosuppressive genes including TIGIT, PDCD1(PD1), LAG3, CTLA4, CD96, CD274(PDL1), BTLA and immunoactivating genes including CD27, CD48, ICOS, LTA, TNFRSF9, TNFSF13B and chemokines including CXCL9, CXCL10, CXCL11, CCL19, CCL5 were strongly correlated with CXCL13 gene expression (p<0.05, R>0.6) in majority cancers (Figure 9).