As a synthesized small-molecule and specific selective agonist of MC1R, 1-[1-(3-methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone (BMS-470539) has been shown to attenuate early brain injury (EBI) following subarachnoid hemorrhage (SAH) by inhibiting oxidative stress, neuronal apoptosis, and mitochondrial fission via MC1R signaling [23, 24]. This evidence concerns the gene MC1R and subarachnoid hemorrhage.