In Model 11 (hierarchically selected covariates of age, serum prealbumin, SCr, serum glucose, history of primary hypertension, history of coronary heart disease, history of diabetes, and history of taking calcium-based phosphate binders), result still remained significant after adjustment for confounding risk factors listed above (HR 2.061, 95% CI 1.030-4.125, P = 0.041) (Table 3). This evidence concerns the gene TTR and essential hypertension.