For example, for insulin secretion (hsa04911), high plasma phospholipid transfer protein (PLTP) is associated with type II diabetes and obesity, while PLTP mediates the net transfer and exchange of phospholipids between different lipoproteins and is strongly associated with the development of atherosclerosis and, thus, angina [71]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.