In addition, the results of a meta-analysis of 28 studies conducted in women with and without PCOS (n = 741 and n = 1224, respectively) showed that a 10 unit higher BMI reduces insulin sensitivity as assessed by euglycemic-hyperinsulinemic clamp by 28% and 15%, respectively, and low SHBG levels are independently associated with a decrease in insulin sensitivity [32]. This evidence concerns the gene INS and polycystic ovary syndrome.