Here, our pyroptosis risk signature was constructed from 11 risk molecules, including MMP1, KPNA2, LPCAT1, NEIL3, CDCA8, SLC2A1, PSRC1, CBX2, HAVCR1, G6PD, MEX3A, of which KPNA2, LPCAT1, CBX2, MEX3A had higher mutation frequencies in patients with HCC. Here, G6PD is linked to hepatocellular carcinoma.