Reck et al. (2019) reported that PD-L1 inhibitor combined with radiotherapy or chemotherapy triggers pyroptosis-induced inflammation within the tumor microenvironment to kill tumor cells. Additionally, Chui et al. (2019) proposed that DPP8/9 inhibitors could cleave NLRP1b to release the C-terminus, thereby triggering caspase-1-induced pyroptosis. Here, CASP1 is linked to neoplasm.