According to the findings of the current study, we strongly proposed a novel proto-oncogene, KDELC1 (POGLUT2), in cancers since it is mainly localized in nucleus and endoplasmic reticulum, it specifically targets extracellular EGF repeats of important proteins involved in Notch signaling pathways, it has interactions with several main proteins involved in cancers, and it is upregulated in several TCGA cancers. The gene discussed is POGLUT2; the disease is cancer.