GSDMC and lumbar spinal stenosis: However, CCDC26/GSDMC rs7833174 have been associated with lumbar microdiscectomy (Bjornsdottir et al., 2017) and lumbar spinal stenosis (Jiang et al., 2020), and a different variant GSDMC rs77681114 have been associated with lumbar disc herniation (Wu et al., 2020).