It also plays an oncogenic role in various human cancers, such as multiple myeloma (van Andel et al., 2017), thyroid carcinoma (Kang et al., 2017), and ovarian cancer (Wang Z. et al., 2020), etc. This paper will systematically summarize LGR4’s role in organ development, energy metabolism and tumor formation, which may provide the fundamental basis for the targeted gene therapy in the future. Here, LGR4 is linked to AL amyloidosis.