LGR4 and gastric cancer: Conversely, Souza, S. M. et al. detected that LGR4 was expressed in a larger number of cells in normal gastric mucosa than in primary gastric carcinomas and not specific to gastric cancer cells, predominantly affecting the expression of β-catenin in membrane-complex but rarely in nucleus, suggesting a controversial function of LGR4, and which was positively correlated with cell proliferation but inversely related to cancer progression (Souza et al., 2019) (Table 5 and Figure 4).