Keratinocytes enhance DcR3 expression in response to epidermal growth factor (EGF), transforming growth factor α (TGFα) and TNFα in psoriasis patients (110), and lung fibroblasts increase DcR3 expression via the Akt/GSK-3β/NFATc1 signaling axis in contact with the collagen matrix in patients with idiopathic pulmonary fibrosis (111). The gene discussed is EGF; the disease is psoriasis.