preliminarily reported an interplay between tumor-secreted IGFBP2 and ATP-dependent chromatin-remodeling enzyme INO80 in pancreatic ductal adenocarcinoma (PDAC) as a conference poster and showed that PDAC tissues often secreted excessive Insulin-like growth factor binding protein-2 (IGFBP2) to pancreatic juice and serum, and tumor-secreted IGFBP2 directly regulated INO80 functions and inhibited MHC class II expression in macrophages (139). Here, IGFBP2 is linked to pancreatic ductal adenocarcinoma.