discovered that leukocytes infiltrating tumors expressed higher ubiquitin-specific peptidase 24 (USP24) levels than surrounding tumor cells in lung cancer patient specimens, and USP24 increased the level of histone H3 acetylation in the promoters of NFKB1 and IL-6 by stabilizing HAT p300, thereby increasing the expression of these genes in M2 macrophages to promote the progression of lung cancer (106). Here, EP300 is linked to lung cancer.