KIT and cancer: SCF binding to the c-Kit extracellular domain induces its dimerization and follow the activation of its intrinsic tyrosine kinase activity that couples with a set of cytoplasmic signalling pathways including mitogen-activated protein kinase pathways (MAPK), fosfoinositide 3-kinase (PI3K) and Src family kinases, resulting in cell proliferation, migration and malignant transformation associated with different genetic diseases and cancers (18, 19).