While Multiple Sclerosis (MS) is the most common cause (1), there is also a spectrum of relatively rare neuroinflammatory and neurodegenerative diseases such as Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein (MOG)-IgG antibody associated disease (MOGAD). The gene discussed is MOG; the disease is neurodegenerative disease.