Furthermore, we examined the correlation between CX3CR1 expression and immune markers of different immune cells using the correlation module of the TIMER database in COAD, including monocyte markers (CD86 and CSF1R), tumor-associated macrophage (TAM) markers (CCL2, CD68, and IL10), M1 macrophage markers (NOS2, IRF5, and PTGS2), and M2 macrophage markers (VSIG4, MS4A4A, and CD163). Here, IRF5 is linked to neoplasm.