After removal of insignificant variables, we found that pathologic stages (TNM) and several genes including GNG8, HRH3, CCL19, CXCR5, SSTR3, OPRL1, CX3CR1, and P2RY13 were significantly correlated with the prognosis of CRC in the univariate Cox analysis. The gene discussed is OPRL1; the disease is colorectal carcinoma.