After removal of insignificant variables, we found that pathologic stages (TNM) and several genes including GNG8, HRH3, CCL19, CXCR5, SSTR3, OPRL1, CX3CR1, and P2RY13 were significantly correlated with the prognosis of CRC in the univariate Cox analysis. Here, GNG8 is linked to colorectal carcinoma.