IL1B and endometriosis: Besides, significant downregulation (p < 0.05) of the level of IL-1β was shown in the culture of endometriosis cells with genistein as compared with control group for 6, 24 and 48 h incubation period (20–50 μM, 5–50 μM and 10–50 μM respectively) (Sutrisno et al., 2014).