Concomitantly, intragastrical administration of genistein for 12 weeks significantly and dose-dependently inhibited HFD induced up-regulation of TNF-α and IL-6 levels, and their mRNA expression (4 mg/kg, p < 0.05 and 8 mg/kg, p < 0.01) in serum and liver of NASH rats (Ji et al., 2011). The gene discussed is IL6; the disease is metabolic dysfunction-associated steatohepatitis.