In line with this, the DRD3 rs6280 that increases the binding affinity of the receptor was associated with a higher chance of TD development (Steen et al., 1997; Basile et al., 1999; Segman et al., 1999, Segman et al., 2002a; Liao et al., 2001; Lerer et al., 2002; Woo et al., 2002; de Leon et al., 2005; Al Hadithy et al., 2009). This evidence concerns the gene DRD3 and thanatophoric dysplasia.