Except for GRIN2A rs7206256, which was associated with orofacial TD (Ivanova et al., 2012b), conflicting results emerged for GRIN2A rs1345423, rs7190619, rs9788936 and rs11646587 (Bakker et al., 2012; Ivanova et al., 2012b; Ivanova et al., 2016b). This evidence concerns the gene GRIN2A and thanatophoric dysplasia.