MAP2K7 and neoplasm: IGF-1R is a transmembrane tyrosine kinase protein with a tetramer structure composed of two subunits, a and ß. The combination of IGF-1 and IGF-1R can activate the PI3K/Akt and Raf1/MEK signaling pathways to suppress the apoptosis and promote the proliferation of tumor cells (Ryan and Goss, 2008; Weroha and Haluska, 2008; Bruchim et al., 2009).