NPPA and cardiac hypertrophy: It was found that administration of magnetic hydrogel nanocomposite-loaded VR in doxorubicin (DOX)–induced cardiotoxicity rat models suppressed MDA by increasing GSH and SOD levels and decreasing mRNA level of cardiac hypertrophy marker ANP, BNP, and β-MHC mRNA in rat heart after 2 weeks intraperitoneal administration (Cheraghi et al., 2017).