The 3xTg-AD mouse [Tg(APPSwe,tauP301L)1Lfa Psen1TM 1Mpm/Mmjax] was developed in 2003 and features three familial AD mutations: the Swedish APP mutation (KM670/671NL), the PSEN1 M146V mutation, and the MAPT P301L mutation (Oddo et al., 2003). Here, MAPT is linked to Alzheimer disease.