PVALB and Alzheimer disease: Our findings regarding the loss of perineuronal nets followed by loss of parvalbumin+ interneurons in the hippocampus of 3xTg-AD mice corroborate prior findings implicating Aβ-dependent microglia activation facilitating the same pathology originally reported in the hippocampus of 5xFAD mice and AD patients (Crapser et al., 2020).