To enable a comparison of an onset of Alzheimer’s-related histopathology between two established animal models of AD, representative sections of 3xTg-AD and 5xFAD mice with their respective wildtype B6/129 and B6J controls were immuno-stained for Thio-S+ dense core plaques and IBA1+ microglia. Here, AIF1 is linked to Alzheimer disease.