ETV6 and acute lymphoblastic leukemia: That said, it is worth recognising the relevance of secondary variants in defining clinical manifestations in inherited malignancies, for instance, ETV6-mutated AML exhibits a distinct somatic profile to acute lymphoblastic leukaemia (ALL) even when arising from the same germline variant, suggesting that cooperating mutations can impact whether a neoplasm develops in the lymphoid or myeloid lineage [2].