RUNX1, CEBPA and GATA2 families exhibited early-onset MDS/AML, with a median age of 10, 18 and 21 years at presentation, respectively, compared with TERT/TERC, SRP72 and DDX41 families who had a longer latency, and a median age of 41.5, 51 and 56 years, respectively (Supplementary Fig. S3). Here, GATA2 is linked to myelodysplastic syndrome.