HIF1A and neoplasm: In analyses of any recurrences in the whole patient material as well as in the non-irradiated group, HIF-1α primary tumour positivity was associated with an increase in early recurrences (HR0–5 years 2, [1.5–2.8], p = 0.0001 and HR0–5 years 1.9, [1.3–2.8], p = 0.001, Fig. 2d, e and Table 2), with a similar pattern in patients with ER-positive and -negative tumours (Supplemental Fig. 2).