HIF1A and neoplasm: There was a higher occurrence of BCD within 10 years of surgery in patients with HIF-1α positive primary tumour in the entire study population and in patients that did not receive RT (HR0–10 years 1.9 [1.2–2.9], p = 0.004, and HR0–10 years 2.1 [1.2–3.7], p = 0.01 Fig. 2g, h and Table 2), while this difference diminished after RT (Fig. 2I).