TIMP1 and colorectal carcinoma: We demonstrated that CRC-derived extravesicular TIMP1 (TIMP1EV) upregulated TIMP1 levels in recipient liver fibroblasts leading to the onset of ECM remodelling; further, the evaluation of TIMP1EV as an intervention target and non-invasive biomarker is warranted to lead to the development of novel treatment strategies for preventing liver metastasis in CRC.