Combined with clinicopathological analysis of patients with HCC, high expression of PSD4 was associated with poor tumor differentiation (P = 0.031), incomplete tumor encapsulation (P = 0.001), advanced tumor TNM stage (P = 0.001), and tumor recurrence (P = 0.001) (Supplementary Table S7). The gene discussed is PSD4; the disease is hepatocellular carcinoma.