ARF6 and hepatocellular carcinoma: More importantly, tail vein injection of these HCC cells showed that overexpression of ARF6Q67L greatly enhanced lung metastasis of SK-Hep1 HCC cells (Fig. 4C, D and Supplementary Fig. S4J) and knocking down of ARF6 suppressed lung colonization of HLF cells (Fig. 4E, F, and Supplementary Fig. S4J), suggesting that the activated ARF6 promotes HCC metastasis.