Studies have showed that AKT1S1 is involve in regulating cell growth, cell apoptosis, oxidative stress, autophagy and angiogenesis through various of signaling pathways such as AKT, mTOR, NF-κB and et al.; AKT1S1 phosphorylation state could predict hyperactivation of the AKT/mTOR pathway in multiple cancer cell types19,33. Here, NFKB1 is linked to cancer.