The Apo-A1 plasma levels were lower in the female than in the male among untreated RRMS patients (Mann–Whitney; P = 0.011, Fig. 3C), and the plasma Apo-A1 levels were decreased in female than in male in the high-risk group (Mann–Whitney; p = 0.001, Fig. 3D). Here, APOA1 is linked to relapsing-remitting multiple sclerosis.