The Concentration of S100A12 in the untreated RRMS group was (mean ± SD = 36.781 ± 48.182 pg/ml), in healthy control (mean ± SD = 42.586 ± 43.641 pg/ml) and in the high-risk group (mean ± SD =15.979 ± 13.163 pg/ml). The gene discussed is S100A12; the disease is relapsing-remitting multiple sclerosis.