Among the five PDEARGs, APOL1 (apolipoprotein L1) with hazard ratio ≤ one was regarded as a protective gene, while the other four genes [DIRAS3 (DIRAS family, GTP-binding RAS-like 3), NAMPT (Nicotinamide phosphoribosyltransferase), P4HB (Proly 4-hydroxylase beta polypeptide), and SPHK1 (Sphingosine kinase-1)] were identified as high-risk genes predicting a poor prognosis of BLCA. The gene discussed is SPHK1; the disease is bladder transitional cell carcinoma.