Here, we focused on 10 frequent oncogenic signaling pathways; cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGF-β, p53 and β-catenin/Wnt signaling which were previously shown to be significant among various cancer types, involving tumorigenesis, cell proliferation, metastasis and angiogenesis34,35. This evidence concerns the gene AKT1 and cancer.