In HD sheep, the biological processes and pathways associated with up-regulated genes indicate activation of repair mechanisms rather than activation of the immune system, specifically ‘tissue morphogenesis’, ‘focal adhesion’, ‘ECM-receptor interaction’, ‘cardiovascular system development’, ‘sensory organ development’, ‘vasculature development’, ‘vascular smooth muscle contraction’ and ‘PI3K-Akt signaling pathway’. Here, AKT1 is linked to Huntington disease.