Notably, FTSig shows to derive more and stronger inverse RRs with EGFR when compared with the FFSig. In addition, our result shows that ERCC1, a key genetic biomarker for NSCLC, is exclusively correlated with a single feature from the FFSig, where the same feature showed inverse RRs with EGFR previously. The gene discussed is ERCC1; the disease is non-small cell lung carcinoma.