To probe this question, peritoneal macrophages were cultured with PBS or WGP in vitro and 7 days later were restimulated with LPS, the supernatant from cells cultured from a naïve mouse pancreas, and the supernatant from cultured KPC cells, which are a cell line of a pancreatic tumor on a C57BL/6 background derived from the LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx1-Cre (KPC) mice or Pan02 pancreatic cancer cells for 24 h. This evidence concerns the gene PDX1 and familial pancreatic carcinoma.