Some interactions were rare or unique to a single fragment from each patient (for example, IL1R-IL1B, IL1R inhibitor-IL1B, HLA-C/FAM3C in glioma to myeloid signaling; CXCL8-ACKR1 in myeloid to glioma signaling, Fig. 5d). This evidence concerns the gene IL1R1 and central nervous system cancer.