IDH1 and glioblastoma: Multivariate analysis of the CGGA GBM only dataset with MC signature genes, gender, recurrence, IDH status, and MGMT promoter methylation status showed significant associations between MC2 and MC7 and improved overall survival and MC3 with worse overall survival (p-values: MC2 = 0.02, MC3 = 0.049, and MC07 = 0.03; multivariate Cox regression analysis; Supplementary Data 10).