MGMT and neoplasm: Importantly, multivariate analysis36 of MC signature scores, tumor subtype, gender, recurrence, IDH status, and MGMT promoter methylation status showed that MC2–MC5, and MC7 signature scores were independent prognostic indicators (multivariate Cox regression analysis p-values: MC2 = 0.04, MC3 = 0.04, MC4 = 0.0007, MC5 = 0.0003, and MC7 = 0.002; Supplementary Data 10).