Moreover, a number of novel HEVs with high ACKR1 expression on its ECs are generated in thyroid tissues of HT patients and facilitate the recruitment of lymphocytes by translocating the chemokines produced by infiltrated immune cells and thyroidal stromal cells such as CCL2 and CCL5, which further exacerbate the infiltration of immune cells in the thyroid tissue of HT patients (Fig. 9). Here, CCL5 is linked to hematocrit.