A strong positive correlation was also found between the percentage of FSH + cells and ERα + cells (Spearman’s rho = 0.67, adjusted p = 0.01) (Table 3), suggesting the existence of tumour areas simultaneously rich and poor in FSH + , ERα + , and S100B + cells (Additional file 3: Fig. S3C). This evidence concerns the gene ESR1 and neoplasm.