While we also found the overall percentage of S100B + cells to positively correlate with the percentage of ERα + cells in gonadotroph tumours, the overall percentage of S100B + cells was not associated with age, gender, invasion or tumour dimension in any of the PitNET subtypes, a result consistent with previous work by Voit et al. in acromegaly patients [25]. This evidence concerns the gene ESR1 and neoplasm.