To address this question, we built a cartography based on the IHC analysis of multiple markers on serial tumour sections, including five new markers, namely Ki67 (a proliferation marker), FSH and LH (the two hormones produced by gonadotroph cells), SSTR2 (a potential marker of response to treatment), and ERα (a transcription factor and a potential marker of response to treatment) [26, 30] (Fig. 5A). The gene discussed is ESR1; the disease is neoplasm.