Although the percentage of intratumoural S100B + cells was not statistically associated with the tumour subtype itself (Fig. 3C), a Ki67 index ≥ 3%, a mitosis count > 2/10 HPFs, and a proliferative status, were all significantly associated with a lower percentage of S100B + cells exclusively in gonadotroph tumours (Fig. 3D–F), but not in Pit1, nor in corticotroph tumours (Additional file 2: Fig. S2A-C and Fig. S2E-G). This evidence concerns the gene S100B and neoplasm.