Precisely, our study showed two types of peripheral immune cells (NEU and LYM), and the ratio of these two cell types (NLR) were associated with AD pathology (CSF Aβ, T-tau), brain metabolism (FDG-PET), global cognition (MMSE, CDRSB and ADAS scores), MEM, EF, and neuroimaging of AD (HV, EC thickness and ventricular volume) at baseline and follow-up, and the pathological effects of these peripheral immune markers were different. Here, MAPT is linked to Alzheimer disease.