In a mouse model with P. aeruginosa VAP, the expression of ICAM and VCAM in the lungs and TNF-α, IL-1β, and IL-6 levels in BALF of wild type mice increased significantly after being infected, while TNF-α is a key regulator of the lung injury caused by P. aeruginosa VAP [49]. The gene discussed is IL1B; the disease is ventilator-associated pneumonia.