We identified four pathways (allograft rejection, interferon gamma response, peroxisome, and TNFA signaling via NFKB) containing gene sets that, with respect to AD, were significantly upregulated in the blood and brain from ε4 carriers and other gene sets from the same pathways that were downregulated in individuals without ε4. This evidence concerns the gene NFKB1 and Alzheimer disease.