Among genes previously associated with AD among ε2/ε3 subjects [19], C4A, C4B, and HSPA2 were moderately (P < 10−3) upregulated in the brain but not blood from AD ROSMAP Study participants in the ε2/ε3 subgroup and total sample (Supplemental Table 5). The gene discussed is C4A; the disease is Alzheimer disease.