CXCR2 and chronic obstructive pulmonary disease: In this study, markers of neutrophil activation such as CD16, CXCR2, as well as percentage of activated neutrophils (+ 12.2% change) in peripheral blood were increased in COPD patients compared to healthy subjects after DE exposure (p = 0.006, p = 0.002, p = 0.046 respectively) [26].