PDCD1 and pachyonychia congenita: In a syngeneic metastatic PC mouse model, combination therapy with GVAX (on day 4, 7, 14, and 21) and anti-PD-1 G4 antibodies (100 μg BIW) improved murine survival compared with anti-PD-1 antibody monotherapy or GVAX therapy alone [136].