Moreover, in a syngeneic orthotopic PC mouse model, the combination of PD-L1 blockade (100 μg BIW for 2 weeks, clone 10F.9G2) with urokinase plasminogen activator receptor-targeted iron oxide nanoparticles loaded with cisplatin (10 mg/kg drug equivalent) decreased tumor burden by ~ 65% [34]. Here, CD274 is linked to pachyonychia congenita.