CD40 and pachyonychia congenita: In a clinical phase Ib study in which CD40 agonist APX005M (sotigalimab, 0.1 mg/kg or 0.3 mg/kg on day 3 or day 10), gemcitabine (1000 mg/m2 on day 1, 8, and 15 every 4 weeks), and nab-paclitaxel (125 mg/m2 on day 1, 8, and 15 every 4 weeks) were combined with nivolumab (240 mg on day 1 and 15 every 4 weeks) to treat 12 metastatic PC patients, 8 achieved PR while 3 displayed SD.