Using a syngeneic orthotropic UN-KC6141 mouse model of PC, 67% of mice survived more than 30 days after tumor inoculation when using ablative RT (a single dose of 25 Gy) and anti-PD-L1 antibodies (10 mg/kg for 5 days), while the median survival time was 16.5 days within the control group. This evidence concerns the gene CD274 and pachyonychia congenita.