In a study in which human PC specimens were harvested and analyzed by organotypic slice culture to test the effects of the combination of anti-PD-1 (20 mg/mL) and CXCR4 inhibitor AMD3100 (100 mg/mL), CD8+ T cell migration and induction of tumor cell apoptosis were observed [91]. The gene discussed is CD8A; the disease is pachyonychia congenita.