CXCR4 and neoplasm: In a syngeneic subcutaneous PC mouse model, the addition of anti-PD-L1 antibodies (160 μg QOD; clone 10F.9G2) to 90 mg/mL CXCR4 inhibitor AMD3100 (using an AZLET osmotic pump) was found to significantly decrease tumor volume (p < 0.01), identified by the loss of heterozygosity of the Trp53 gene [90].