In a preclinical study using a KPC syngeneic PC mouse model, Wang et al. found that oVV-LZ8 (where the oVV-gene is an oncolytic vaccinia virus platform and LZ8 is an immunomodulatory protein isolated from Reishi, capable of promoting cell proliferation and IL-2 production in T cells) enhanced the tumor inhibitory effects of anti-PD-1 antibody in vivo. The gene discussed is PDCD1; the disease is pachyonychia congenita.