In mice bearing subcutaneous MT5 and Panc02 tumors, the combination blockade of anti-IL-6 antibody (200 μg/mouse, TIW for 2 weeks; clone MP5-20F3) and anti-PD-L1 antibody (200 μg/mouse, TIW for 2 weeks; clone 10F.9G2) was found to inhibit tumor volume (p < 0.05 compared with monotherapy using either) in CD8+ T cell-dependent approaches [70]. This evidence concerns the gene CD274 and neoplasm.