Lymphokine-activated killer T (T-LAK)-cell-originated protein kinase (TOPK) is a member of the serine-threonine kinases of the mitogen-activated protein kinase kinase (MAPKK) family and is highly expressed in many cancers, including adult T-cell leukaemia/lymphoma (ATLL) and B cell lymphoma [6–10]. Here, PBK is linked to cancer.