When the order of infection was inverted (LAIV infection occurred 3 days before pneumococcal challenge) (19), the levels of influenza-specific IgA did not differ between Spn-colonized and noncolonized participants (IgA median 1.5- and 1.6-fold increase, respectively; P = 0.28) (Supplemental Figure 3B). This evidence concerns the gene CD79A and infection.