According to previous studies, COL1A1 increases cell proliferation, colony-forming efficiency, migration ability, and invasion ability [51]; besides its role in the induction of epithelial-mesenchymal transition (EMT) through the TGF-β-dependent pathway, COL1A1 might be a candidate diagnostic, prognostic, and chemoresistance biomarker for lung cancer patients [52]. The gene discussed is COL1A1; the disease is lung cancer.