LCN2 and obesity due to melanocortin 4 receptor deficiency: In our cohort, a cross-sectional study showed that serum LCN2 levels were associated with several adiposity variables, including BMI, weight, waist circumference, and hip circumference, which concurs with a previous study in 229 adults, suggesting that increased fat mass might partly account for elevated serum LCN2 levels in humans with obesity [26].