Lean participants were also more likely to have lower circulating concentrations of biomarkers of the metabolic syndrome such as leptin (660.9 [174.5–1993.1] pg/ml vs 3988.0 [1336.0–6595.0] pg/ml, p<0.001), and uric acid (246.5 [205.0–290.6] μmol/l vs 289.0 [234.0–347.0] μmol/l, p<0.001). The gene discussed is LEP; the disease is metabolic syndrome.