In vitro study showed that Oligomeric amyloid-β (Aβ) directly inhibits the MT-dependent ATPase activity of KIF2C and leads to abnormal mitotic spindles, which may cause chromosome mis-segregation and increased aneuploid neurons and thereby contributes to the development of Alzheimer’s disease (Borysov et al., 2011). The gene discussed is DNAH8; the disease is Alzheimer disease.