SPAG5 is consistently expressed at higher levels in many types of cancers, such as breast cancer [10,38,39], gastric cancer [13], cervical cancer [40], prostate cancer [12], ovarian cancer [41], osteosarcoma [18], hepatocellular carcinoma [42], bladder cancer [43] and lung cancer [44]. Here, SPAG5 is linked to ovarian carcinoma.