Thus, to test FuG1 mediated blockade of viral infections, we generated replication-defective WT and furin mutant (RRAR-GSAA: ΔRRAR) spike expressing luciferase-VSV pseudovirions named rVSV-spike*ΔG (WT-spike-rVSV) and rVSV-ΔRRAR-spike*ΔG (ΔRRAR-spike-rVSV) (Fig. 6A), without any prior antibody treatments as described earlier (5, 6, 37, 38). Here, FURIN is linked to viral infectious disease.