An early report demonstrated that the small GTPases Rab5 and Rab7, which are commonly involved in virus trafficking through the early endosome (Rab5) and the late endosome (Rab7), were involved in the infection of susceptible cells by quasi-enveloped HEV virions other than naked virions (59), whereas HEV-VLPs were internalized via a dynamin-2-, clathrin-, and membrane cholesterol-dependent pathway (57, 58). This evidence concerns the gene RAB5A and infection.