APOE and Alzheimer disease: (2017) found that the amplitude of low frequency fluctuations (ALFFs) in the left inferior frontal gyrus and left insula among cognitively normal elderly Apolipoprotein E (APOE) carriers was significantly increased compared with those of cognitively normal elderly non‐APOE carriers and MCI/AD APOE carriers, and importantly, decreased ALFF values in the left inferior frontal gyrus, and insula were correlated with the effect of amyloid complexes on memory impairment.