NLRP3 and multiple sclerosis: Given that DMF is able to potently inhibit NLRP3 activation and directly inhibit gasdermin D cleavage [19] and that NLRP3 is detrimental in the experimental autoimmune encephalomyelitis model of multiple sclerosis [36, 43, 44], it is possible that DMF's protective response in multiple sclerosis is in part mediated through dampened microglial and macrophage NLRP3 activation that may promote neuronal demyelination.