Given that DMF is able to potently inhibit NLRP3 activation and directly inhibit gasdermin D cleavage [19] and that NLRP3 is detrimental in the experimental autoimmune encephalomyelitis model of multiple sclerosis [36, 43, 44], it is possible that DMF's protective response in multiple sclerosis is in part mediated through dampened microglial and macrophage NLRP3 activation that may promote neuronal demyelination. Here, GSDMD is linked to multiple sclerosis.