This has been already reported among individuals with 5ARD2 and PAIS at puberty, occurring after LH hyperstimulation through a negative feedback mechanism in 5ARD2, with reductions in DHT and in PAIS, owing to testosterone activity.33 However, further research on INSL3 behavior in 46,XY DSD patients is required in order to elucidate this trend. The gene discussed is INSL3; the disease is disorder of sexual differentiation.