NR2E3 and acute myeloid leukemia: Recently, biochemical and cell-culture studies have revealed that clorfarabine (ClF), a nucleoside therapeutic used in the treatment of acute lymphoblastic and acute myeloid leukemias, subsequent to its phosphorylation to a di- or trinucleotide (ClFDP, ClFTP) binds to the α subunit of human Ia RNR and potentiates formation of the α6 inhibited state (Aye and Stubbe, 2011; Brignole et al., 2018).